A Babsky, Ju Shenghong - Apparent diffusion coefficient of waterin evaluation of treatment response in animal body tumors - страница 3

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CONCLUSION

DWI is a powerful, non-invasive MRI tool that provides unique information related to structural, cellular, apoptotic, and necrotic changes in tumor tissue. The technique can be used widely for tumor detection and characterization and for monitoring of re­sponse to treatment. Effective tumor therapy is usually associated with an increase in ADC values, although exceptions may occur. WaterADC appears to have the ability to predict treatment response to chemotherapy. However, there are several challenges to wider use of DWI in cancer patients. These include a lack of accepted standards for data acquisition and analysis, variability of ADC changes depending on tumor cell type and location, motion effects on body tumorADC measurements, incomplete theoretical understanding of DWI in ECS and ICS, and poorly understood multiexponential decay components which affect the calculated ADC values. Thus, DWI protocols and analyses need to be adapted to individual tumor types, anatomic locations and therapies. We also need a better understanding of how tumor water ADC measurements can be com­bined with results of other diagnostic modalities, such as 23Na MRI, 31P MR spectro­scopy, positron emission tomography, destructive chemical analysis, and histology, to improve our assessment of prognosis and better monitoring oftherapeutic efficiency.

Acknowledgements

The authors thank Samuel G. Jennings for valuable comments and assistance in the preparation of the manuscript.

ВИКОРИСТАННЯ КОЕФІЦІЄНТА ДИФУЗІЇ ВОДИ ДЛЯ ОЦІНКИ ЕФЕКТИВНОСТІ ТЕРАПІЇ ЕКСПЕРИМЕНТАЛЬНИХ ПУХЛИН У ТВАРИН

A. M. Бабський 1,2, Ш. Джи 1,3, Н. Банзал 1

1 Відділ радіологіїіндіанського університету, Індіанаполіс, Індіана 46202, США 2Львівський національний університет імені Івана Франка, вул. Грушевського, 4, Львів 79005, Україна 3Центральний госпіталь Південно-східного університету, Нанджін 210009,

Народна Республіка Китай e-mail: ababsky@iupui.edu

У статті підсумовано власні результати авторів і літературні дані, присвячені ви­користанню показників дифузії води, що вимірюються методом дифузійно-граді-

єнтних зображень ядерно-магнітного резонансу, для оцінки структурних та внутріш-ньоклітинниих змін, пов'язаних із апоптозними чи некротичними трансформаціями у ракових пухлинах. Обговорюється можливість використання змін коефіцієнта ди­фузії води для ранньої діагностики, оцінки ефективності протипухлинної терапії та з'ясування механізмів канцерогенезу на прикладах експериментальних пухлин, прищеплених тваринам.

Ключові слова: пухлина, хіміотерапія, коефіцієнт дифузії води, Натрій, ядерно-магнітний резонанс.

ИСПОЛЬЗОВАНИЕ КОЭФФИЦИЕНТА ДИФФУЗИИ ВОДЫ ДЛЯ ОЦЕНКИ ЭФФЕКТИВНОСТИ ТЕРАПИИ ЭКСПЕРИМЕНТАЛЬНЫХ ОПУХОЛЕЙ У ЖИВОТНЫХ

A. M. Бабский [2], Ш. Джи 1,3, Н. Банзал [3]

Ютдел радиологии Индианского университета, Индианаполис, Индиана 46202, США 2Львовский национальный университет имени Ивана Франко, ул. Грушевского, 4, Львов 79005, Украина 3 Центральный госпиталь Юго-восточного университета, Нанджин 210009, Народная Республика Китай

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A Babsky, Ju Shenghong - Apparent diffusion coefficient of waterin evaluation of treatment response in animal body tumors